Shining light on an amygdala-brainstem connection relevant for attention processing

Shining light on the vitamin D: Cancer connection IARC report.

Shining a light on an opportunistic pathogen.

The surface of our planet is subjected to dramatic changes in levels of solar radiation on a daily basis. Sunlight is the direct energy source for photosynthetic organisms and is the foundation of most of the food chains that support heterotrophs like ourselves. Not surprisingly, plants and photosynthetic microorganisms sense and respond to light in many ways. Bacterial light sensors are divers...

Shining a light on optogenetics

O ptogenetics is relatively new and has attracted much interest since the first publications from the field in the early 2000s. Both researchers and the media are fascinated by the notions it conjures of bionic implants. Notwithstanding potential applications, the technology has quickly become an important research tool in neuroscience with potential for developing a range of novel therapeutic ...

Shining light on "Dark Winter".

On 22--23 June 2001, the Johns Hopkins Center for Civilian Biodefense Strategies, in collaboration with the Center for Strategic and International Studies, the Analytic Services Institute for Homeland Security, and the Oklahoma National Memorial Institute for the Prevention of Terrorism, held a senior-level exercise entitled "Dark Winter" that simulated a covert smallpox attack on the United St...

Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective

Metabotropic glutamate receptors (mGluRs) are important drug targets because of their involvement in several neurological diseases. Among mGluRs, mGlu5 is a particularly high-profile target because its positive or negative allosteric modulation can potentially treat schizophrenia or anxiety and chronic pain, respectively. Here, we computationally and experimentally probe the functional binding ...